Journal of Pathology and Translational Medicine

Case Study

Primary Cutaneous Mucinous Carcinoma with Extramammary Paget’s Disease: Eccrine or Apocrine?: Sun-Ju Oh, Young-Ok Kim; J Pathol Transl Med. 2018;52(4):238-242. Published online January 25, 2018; DOI: https://doi.org/10.4132/jptm.2017.11.21

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Primary cutaneous mucinous carcinoma (PCMC) is an uncommon tumor of the sweat gland origin. The occurrence of PCMC is mostly in middle-aged and older patients, with a slight male predominance. Most cases of PCMC arise on the head, with a preference for eyelids. The histogenesis of PCMC, whether eccrine or apocrine, remains controversial. We report a rare case of PCMC with secondary extramammary Paget’s disease in the groin of a 75-year-old man, which favored an apocrine origin. Furthermore, based on a review of the literature, we provide several histologic clues that can be used to differentiate PCMC from metastatic mucinous carcinoma.

Citations

Citations to this article as recorded by

Primary cutaneous mucinous carcinoma of the scalp masquerading as a benign dermatological mass – A case report
Fadi Alnehlaoui, Nafad Mohamed Lotfy Elhadidi, Shafik Fwakhrji, Shekhar V. Shikare, Majid Hassan Alhammadi, Salman Yousuf Guraya
International Journal of Surgery Case Reports.2024; 114: 109175. CrossRef
Primary Cutaneous Mucinous Carcinoma: A Review of the Literature
Timothy Freeman, Aaron J. Russell, M. Laurin Council
Dermatologic Surgery.2023; 49(12): 1091. CrossRef
A Case of Eccrine Mucinous Carcinoma Involving Scalp
Ramsha Saleem, Sachin Vaidya
Cureus.2021;[Epub] CrossRef

Brief Case Reports

Late Bone Metastasis of Histologically Bland Struma Ovarii: The Unpredictability of Its Biologic Behavior: Sun-Ju Oh, Minjung Jung, Young-Ok Kim; J Pathol Transl Med. 2015;49(4):343-345. Published online June 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.27

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Citations

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Malignant struma ovarii with late recurrence harbouring high microsatellite instability
Su Yun Chung, Jeffrey Chi, Jennifer Park, Veena John, Nagashree Seetharamu
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Juliane Comunello, Fábio Fernando Eloi Pinto, Suely Akiko Nakagawa, Wu Tu Chung, Felipe D’Almeida Costa, Américo Delgado Brilhante
JBJS Case Connector.2017; 7(4): e82. CrossRef

Lipoma within Inverted Meckel's Diverticulum: A Case Report: Su-Mi Kim, Min-Jung Jung, Young-Ok Kim; Korean J Pathol. 2013;47(1):86-88. Published online February 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.86

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Original Article

Clinicopathologic Implications of PIWIL2 Expression in Colorectal Cancer: Sun-Ju Oh, Su-Mi Kim, Young-Ok Kim, Hee-Kyung Chang; Korean J Pathol. 2012;46(4):318-323. Published online August 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.318

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Abstract PDF

Background

There are no established reports about the expression of the Piwil gene, a subfamily of the Piwi gene involved in RNA silencing and self-renewal, in colorectal carcinomas. It is known that the degree of PIWIL2 expression is higher in colorectal carcinomas. But its clinicopathologic significance remains undetermined. This study reassessed the relationship between PIWIL2 expression and the clinicopathologic parameters in colorectal carcinomas.

Methods

An immunohistochemistry of PIWIL2 expression was done in 60 cases of colorectal carcinoma. This was followed by an analysis of the correlation between PIWIL2 expression and clinicopathologic features and a survival analysis.

Results

There were 44 cases (73.3%) where the degree of PIWIL2 expression was relatively higher. The high degree of PIWIL2 expression was significantly correlated with the lower degree of differentiation (p=0.039), deep invasion (p=0.019) and perineural invasion (p=0.027). The overall survival was longer in patients with the lower degree of PIWIL2 expression than in those with the higher degree of PIWIL2 expression.

Conclusions

Our results showed that the degree of PIWIL2 expression was relatively higher in colorectal carcinomas and it was significantly correlated with variable clinicopathologic indicators for a poor prognosis. This indicates that PIWIL2-positive cells contribute to the progression of colorectal cancer.

Citations

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